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September 1965

Myelin Artifacts in the Optic Disc and Retina

Author Affiliations

Washington, DC
From the Ophthalmic Pathology Branch, Armed Forces Institute of Pathology, Chief, Dr. Zimmerman and Research Associate.

Arch Ophthalmol. 1965;74(3):394-398. doi:10.1001/archopht.1965.00970040396020

In 1958 Cogan and Kuwabara1 called attention to the previously undescribed, often confusing, and sometimes misleading accumulations of myelin in the peripapillary retina and choroid that may be formed when, in enucleating the eye, the optic nerve is crushed very close to the globe (Fig 1). Their paper, published in a nonophthalmic journal, has apparently not come to the attention of many ophthalmologists, for it has been our experience that this "lesion" continues to confuse many students of ophthalmic pathology. For this reason, and because we wish to record some additional observations not included in the original paper by Cogan and Kuwabara, the present paper has been prepared. These accumulations of myelin appear in routine histopathologic sections as amorphous granular eosinophilic deposits containing a few illdefined nuclei. They vary greatly in size, shape, and position, but most often as described by Cogan and Kuwabara, they are encountered in the

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