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October 1965

Therapy of Experimental Vaccinal Keratitis: Effect of Idoxuridine and VIG

Author Affiliations

Preliminary results read before the Western Society for Pediatric Research, Salt Lake City, Nov 17, 1964. Assistant Professor of Pediatrics, University of Colorado School of Medicine, Markle Scholar in Academic Medicine (Dr. Fulginiti); Clinical Assistant in Ophthalmology, University of Colorado School of Medicine (Dr. Winograd); Professor and Head, Division of Ophthalmology, University of Colorado School of Medicine (Dr. Ellis). Dr. Jackson was a Senior medical student during the performance of this study.

Arch Ophthalmol. 1965;74(4):539-544. doi:10.1001/archopht.1965.00970040541019

Introduction  One of the less common, but serious complications of smallpox vaccination is accidental inoculation of the cornea with vaccinia virus. Acute inflammatory changes associated with prolonged disability due to corneal clouding can follow vaccinal keratitis.1 Various modes of therapy have been employed.1-3 For these reasons, a systematic attempt was made to evaluate two of the more recently employed therapeutic regimens, and the results are the basis of this report.


Rabbits.  —Four-week-old Swiss albino rabbits weighing approximately 1 kg were obtained from a local rabbitry.* Animals were observed for several days prior to beginning an experiment as occasional rabbits did not survive abrupt weaning.

Virus.  —Several vaccinia strains were employed in preliminary studies and variable corneal infection rates and severity were noted with all but a tissue-culture adapted calf-lymph-origin strain. A commercial product † prepared in calf skin and packaged in capillary tubes was obtained. Twelve capillary

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