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October 1965


Author Affiliations

441 E 68th St New York, NY 10021

Arch Ophthalmol. 1965;74(4):554. doi:10.1001/archopht.1965.00970040556024

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To the Editor:  Dimethylsulfoxide (DMSO) has been shown to be an active agent against ocular and intraocular inflammations. Its results have been so variable and unpredictable as to indicate that much is still to be learned about its proper usage. For that reason I have not attempted a more detailed analysis of my series of cases treated. However, the number of inquiries addressed to me prompt this letter.In over one year's experience, after first testing the material on rabbit eyes and blind human eyes, I have found that most patients will tolerate the solution in up to 66% concentrations or higher without exhibiting an induced keratitis. In the higher concentrations, conjunctival irritation and injection may occur and warrant reduction of the concentration.Not a single significant (5 points or more) rise in intraocular pressure has been seen. The drug has been disappointing in the management of extraocular allergy, and

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