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December 1965

Intraocular Pressure and Facility in Monkeys After Water Drinking: A Study in the Cynomolgus Monkey, Macaca irus

Author Affiliations

San Francisco
From the Department of Pharmacology, Uppsala University, Uppsala, Sweden.

Arch Ophthalmol. 1965;74(6):841-844. doi:10.1001/archopht.1965.00970040843021

It is well accepted that the rise in intraocular pressure seen in both normal and glaucomatous eyes following ingestion of a substantial volume of water is accompanied by a reduction in blood tonicity.1,2 This sudden change in osmolarity of the blood presumably promotes an increased rate of influx of water into the eye. It has been reported that outflow facility decreases following water ingestion and that this too may contribute to the pressure rise. This has been observed in both normal and glaucomatous eyes, but to a much greater extent in the latter.3 Other authors4,5 have reported little or no effect on facility after water. It has also been reported that in normal eyes there is an increase in facility following water while in glaucomatous eyes facility remains unchanged.6

All of these studies have used tonography to assess facility. It is known that tonography has many

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