Clinically normal eyes were found to demonstrate different magnitudes of ocular hypertensive response when subjected to identical concentration, frequency, and duration of topical application of dexamethasone 21-phosphate. The search for a response measure which maximizes the detection of this heterogeneity led to the selection of the change in applanation pressure after four weeks of topical application of 0.1% dexamethasone three times daily. In the case of this measure, the hypothesis that the data represent a single homogeneous population had to be rejected at the 1% level of confidence.1
Using the above measure, 80 subjects with clinically normal eyes were shown to demonstrate three distinct and statistically different levels of response: low, intermediate, and high. Table 1 summarizes the characteristics of each level; ie, the range encountered in the sample, the mean, and the standard deviation, as well as the number of individuals and percent of the sample that demonstrated
ARMALY MF. The Heritable Nature of Dexamethasone-Induced Ocular Hypertension. Arch Ophthalmol. 1966;75(1):32–35. doi:10.1001/archopht.1966.00970050034007
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