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January 1966

Amyloidosis of the Eyelid and Conjunctiva

Author Affiliations

Washington, DC
From the Registry of Ophthalmic Pathology, Armed Forces Institute of Pathology, Washington, DC 20305.; Work was done during tenure of a Special Fellowship in Ophthalmic Pathology of the National Institute of Neurological Diseases and Blindness, NIH, at the Armed Forces Institute of Pathology (Dr. Smith). Present address: Department of Ophthalmology Washington University School of Medicine, St. Louis, Mo 63110. Chief, Ophthalmic Pathology Branch, Armed Forces Institute of Pathology (Dr. Zimmerman).

Arch Ophthalmol. 1966;75(1):42-51. doi:10.1001/archopht.1966.00970050044009

Amyloidosis may be considered a group of disorders of diverse etiology and pathogenesis that have in common certain characteristic histopathologic features. Their essential unifying characteristic is the deposition in various tissues of a hyaline substance that can be distinguished from other types of hyalin by use of appropriate histopathologic technics. The exact nature of amyloid remains to be determined, however, and, in fact, there is reason for believing that amyloid deposits vary in composition sufficiently to form a spectrum from typical amyloid to nonspecific hyalin. The term "paramyloid" has been introduced to designate hyaline deposits that give atypical or inconsistent staining reactions for amyloid.

Several recent publications1-6 have reviewed the various concepts of the nature and pathogenesis of amyloidosis, but the clinicopathologic classification offered by Reimann and co-workers7 30 years ago continues to enjoy general acceptance:

  1. Primary amyloidosis, in which there is no known predisposing disease, characterized