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January 1966

Experimental Transient Glaucoma in Animals

Author Affiliations

Augusta, Ga
From the Department of Surgery (Ophthalmology), Medical College of Georgia, Augusta.

Arch Ophthalmol. 1966;75(1):92-98. doi:10.1001/archopht.1966.00970050094020

Bartels1 in 1905 described a glaucoma in dogs and rabbits which followed ligating or cutting of the extraocular muscles. It was assumed that the effect was a result of occlusion of the anterior ciliary veins, although just how this venous congestion would result in a glaucoma was not adequately defined. In view of the accumulating evidence for a neurohumoral homeostatic control mechanism regulating the intraocular pressure, the present study was undertaken to further explore the various factors involved in the production of this interesting glaucoma.

Method and Material  Adult albino rabbits (2 to 4 kg [4.4 to 8.8 lb]) and adult mongrel dogs (8 to 10 kg [17.6 to 22 lb]) anesthetized with intravenous secobarbital were used. In all experiments following the induction of general anesthesia, the ocular tension was measured at ten-minute intervals until stable readings were obtained (usually 30 to 40 minutes). The same certified Schiøtz tonometer