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February 1966

The Relationship Between Autoantibody and Sympathetic Uveitis

Author Affiliations

St. Louis; San Francisco
From the Eye Research Laboratories, Department of Ophthalmology University of California School of Medicine, San Francisco General Hospital, and the Clinical Laboratories, San Francisco General Hospital.

Arch Ophthalmol. 1966;75(2):213-217. doi:10.1001/archopht.1966.00970050215014

The observation that "sympathetic uveitis" occurs in the second eye of experimental animals after intraocular inoculation of the first eye has been reported frequently during the past 50 years.1-5 The postulated causes for this disease have been organismal, neurogenic, and autoimmune; yet a definitive study validating such a mechanism has not been accomplished. This study shall evaluate the relationship between autoantibody production and the occurrence of disease.

Materials and Methods  Outbred pigmented guinea pigs were divided into four experimental groups. These included: 43 animals in groups 1 and 2, which were systemically immunized to bovine serum albumin (BSA) utilizing a modification6 of Freund's adjuvant-alum technique. Animals were initially intracutaneously immunized to 2.0 mg BSA in complete Freund's adjuvant (1:1); 0.1 ml was injected into each of the four foot pads. After 19 days each animal received 1.0 mg BSA (alum precipitated) intramuscularly for three successive days. Such sequences