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March 1966

Clinical and Pathological Study of Choroidal Lipid Globules

Author Affiliations

From the Howe Laboratory of Ophthalmology, Harvard University Medical School, and the Eye Pathology Laboratory, Massachusetts Eye and Ear Infirmary.

Arch Ophthalmol. 1966;75(3):334-336. doi:10.1001/archopht.1966.00970050336006

Lipid deposits in the form of globules have been observed in the choroid of a number of the specimens studied in this laboratory. A study was undertaken to determine the incidence and clinical significance, if any, of these lipid globules.

The subject of fatty degeneration of the choroid has been reviewed by Jaensch.1 He considered the presence of large amounts of lipid in the choroid to be a sign of severe pathology in the eye. It is the purpose of this paper to describe the appearance of these lipid globules during life and to describe their histopathologic characteristics in otherwise normal eyes.

Methods and Materials 

Histopathology.  —The observations reported in this study are based upon the examination of the choroid of approximately 100 pairs of eyes which were obtained post mortem. The specimens were examined with a dissecting microscope after removal of the retinal pigment epithelium from the choroid.

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