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June 1966

Comparative Study of Four Different Epinephrine Salts on Intraocular Pressure

Author Affiliations

Vancouver, BC, Canada
From the departments of ophthalmology, University of British Columbia, and Shaughnessy DVA Hospital, and the Ophthalmology Service, Vancouver General Hospital, Vancouver, BC.

Arch Ophthalmol. 1966;75(6):768-770. doi:10.1001/archopht.1966.00970050770010

The use of topical epinephrine to reduce intraocular pressure in the medical management of open angle glaucoma is now well established.1-5 It has been suggested that epinephrine causes a reduced rate of aqueous production and also changes in the trabecular meshwork which lead to an increase in outflow facility.1,2 In most individuals these effects occur within four to five hours following a single dose of topical epinephrine.4

In order to overcome certain undesirable features of these agents, a number of salts of epinephrine in various concentrations are available for topical use.5 The purpose of this study was to compare the effects of the various forms of topical epinephrine on the intraocular pressure and outflow facility of normal and glaucomatous eyes.

Method  Epinephrine bitartrate 2% (Epitrate), epinephrine hydrochloride 2% (Glaucon), epinephrine borate 1% (Eppy), and epinephrine bitartrate 2% without preservatives (Vancouver General Hospital Pharmacy) were the four