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July 1966

Recurrence of Malignant Melanoma in an Orbit After 28 Years

Author Affiliations

Madison, Wis
From the divisions of ophthalmology and surgical pathology, University of Wisconsin Medical School, Madison, Wis.

Arch Ophthalmol. 1966;76(1):79-81. doi:10.1001/archopht.1966.03850010081016

Report of a Case  In 1964, at the age of 69 years, a white male farmer presented with a history of inflammation in the right orbit for the past six months. It had not responded to treatment by various topical medications. A biopsy revealed malignant melanoma.Past history revealed that he had had the right eye enucleated 28 years previously, in 1936 when he was 41 years old, because of malignant melanoma.Examination of the right eye removed in 1936 showed extension of the tumor into the optic nerve and into the subarachnoid space about the optic nerve (Fig 1). The cells were mostly spindle A, a few spindle B, and no epithelioid cells. Mitotic figures were very rare (Fig 2).An exenteration of the right orbit was done in November 1964 after extensive studies failed to reveal any evidence of metastatic disease. The right orbit filled in with granulation

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