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August 1966

Ocular Complications of Hemophilia

Author Affiliations

From the Department of Ophthalmology, Hospital of the University of Pennsylvania, Philadelphia General Hospital, Veterans Administration Hospital, and the Children's Hospital of Philadelphia, Philadelphia.

Arch Ophthalmol. 1966;76(2):230-232. doi:10.1001/archopht.1966.03850010232014

This paper presents the ocular complications occurring in a series of 123 patients with hemophilia. In one of these patients a severe spontaneous retrobulbar hemorrhage resulted in loss of vision in the affected eye. Prolonged bleeding followed extraocular muscle surgery, enucleation, chalazion surgery, and cataract extraction in other patients. In addition, 20 patients with hemophilia were noted to have subconjunctival hemorrhage or other hemorrhages about the eye.

Hemophilia is a hereditary disorder transmitted by the female and affecting males almost exclusively. The disease is due to a reduction or absence of a component in the blood essential for the formation of plasma thromboplastin. Common signs of hemophilia include subcutaneous and intramuscular hemorrhage, bleeding from the mouth or gums, gastrointestinal and genitourinary tract bleeding and hemorrhage into joints. Trivial injury can result in serious and prolonged bleeding. Ocular involvement has only rarely been reported.1-4

Report of Cases 

Patient 1.  —A