Significant rises of intraocular pressure have been observed after topical administration of certain corticosteroids.1-10 These changes were noted in all patients with proved open-angle glaucoma, in most open-angle glaucoma suspects, in many relatives of glaucoma patients, and in some normal volunteers. Patients with primary open-angle glaucoma responded to topical steroids with marked pressure elevation. The response appeared to be distributed as a single gaussian population. The pressure rise induced in normal volunteers showed a bimodal or trimodal distribution. On the basis of these observations and the study of the response in families of glaucoma patients, it was postulated that the intraocular response to topical corticosteroid was genetically determined and inherited in dominant fashion.3-10 It was further suggested that patients with primary open-angle glaucoma behave as if they were homozygous for the responsive trait. According to this hypothesis, the steroid provocative test could reveal the heterozygous or carrier state
BECKER B, CHEVRETTE L. Topical Corticosteroid Testing in Glaucoma Siblings. Arch Ophthalmol. 1966;76(4):484–487. doi:10.1001/archopht.1966.03850010486004
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