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October 1966

Exfoliation Syndrome: Incidence and Prognosis of Glaucoma Capsulare in Massachusetts

Author Affiliations

From the Howe Laboratory of Ophthalmology and Glaucoma Consultation Service, Harvard University Medical School, Massachusetts Eye and Ear Infirmary, Boston. Dr. Hørven is now at Rikshospitalet, Oslo, Norway.

Arch Ophthalmol. 1966;76(4):505-511. doi:10.1001/archopht.1966.03850010507008

In Norway we are not fully satisfied with the results obtained in our chronic open-angle glaucoma treatment. This may be due to the fact that 80% to 90% of our "primary" open-angle glaucomas also exhibit exfoliation syndrome ("pseudoexfoliation of the lens capsule").1-3 As suggested by Vogt,4 this type of glaucoma may be called glaucoma capsulare. It is usually classified as a secondary glaucoma, as exfoliative substance has been demonstrated in the intratrabecular spaces, probably interfering with the drainage of aqueous humor causing rise in intraocular pressure.5,6 A difference in trabecular meshwork pigmentation is found between primary open-angle glaucoma and glaucoma capsulare eyes, the latter being more heavily pigmented.7,8 A recent study by Tarkkanen9 indicates that a difference also may exist in prognosis.

It is well known that the incidence of exfoliation syndrome in patients with "primary" open-angle glaucoma is reported differently in different countries; ranging

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