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October 1966

Effect of Lid Closure in Drug-Induced Experimental Cataracts: Chlorpromazine, Morphine, and Epinephrine

Author Affiliations

Portland, Ore
From the John E. Weeks Memorial Laboratory, Department of Ophthalmology, University of Oregon Medical School, Portland, Ore.

Arch Ophthalmol. 1966;76(4):599-601. doi:10.1001/archopht.1966.03850010601022

Acute lens opacities produced in rodents by chlorpromazine, morphine and related narcotics, and epinephrine alone or combined with ergamine acid phosphate were prevented by closure of the eyelids. The cause of these cataracts is primarily dehydration through the exposed cornea, although other factors contribute to the formation of the opacity. These lens opacities should be carefully differentiated from toxic lens opacities in humans. In future acute experimental cataract investigations, consideration of the effect of lid position on cataract formation is necessary to avoid invalid conclusions.