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October 1966

Ocular Penetration Studies: II. Topical Administration of Prednisolone

Author Affiliations

Columbus, Ohio
From the Department of Ophthalmology, College of Medicine, and Department of Veterinary Medicine, College of Veterinary Medicine, Ohio State University, Columbus.

Arch Ophthalmol. 1966;76(4):602-603. doi:10.1001/archopht.1966.03850010604023

This study has outlined the rate and duration of penetration of tritiated prednisolone into the aqueous humor following a single clinical dose. The prednisolone labeled with tritium was incorporated into a commercial preparation. The concentration of drug reached a peak of 7.651μg/gm of aqueous humor at 30 minutes and decreased to a level of 2.176μg/gm at 240 minutes. These results are compared with the penetration of tritiated dexamethasone.

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