This study has outlined the rate and duration of penetration of tritiated prednisolone into the aqueous humor following a single clinical dose. The prednisolone labeled with tritium was incorporated into a commercial preparation. The concentration of drug reached a peak of 7.651μg/gm of aqueous humor at 30 minutes and decreased to a level of 2.176μg/gm at 240 minutes. These results are compared with the penetration of tritiated dexamethasone.
MURDICK PW, KEATES RH, DONOVAN EF, WYMAN M, SHORT C. Ocular Penetration Studies: II. Topical Administration of Prednisolone. Arch Ophthalmol. 1966;76(4):602–603. doi:10.1001/archopht.1966.03850010604023
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