[Skip to Content]
[Skip to Content Landing]
October 1966

Ocular Penetration StudiesII. Topical Administration of Prednisolone

Arch Ophthalmol. 1966;76(4):602-603. doi:10.1001/archopht.1966.03850010604023

This study has outlined the rate and duration of penetration of tritiated prednisolone into the aqueous humor following a single clinical dose. The prednisolone labeled with tritium was incorporated into a commercial preparation. The concentration of drug reached a peak of 7.651μg/gm of aqueous humor at 30 minutes and decreased to a level of 2.176μg/gm at 240 minutes. These results are compared with the penetration of tritiated dexamethasone.