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March 1967

Topical Steroids and Tritiated Thymidine Uptake: Effect on Corneal Healing

Author Affiliations

New York
From the Corneal Center, Institute of Ophthalmology College of Physicians and Surgeons, Columbia University, New York.

Arch Ophthalmol. 1967;77(3):400-404. doi:10.1001/archopht.1967.00980020402020

The effect of topically applied 1% medrysone and 0.05% dexamethasone ointment (Decadron) three times a day was studied in rabbit corneas with circular stromal injuries caused by a cryocautery.

There was a marked decrease in the uptake of the tritiated thymidine in steroid-treated corneas 24 hours after the injury. This decrease in the number of labeled cells paralleled a twofold decrease in wound healing measurements at the end of five days. It is suggested that cortisone decreases the healing of corneal stromal wounds by inhibiting deoxyribonucleic acid synthesis of regenerating connective tissue cells.