Exophthalmos has been found in 6% to 8% of Cushing's disease with elevated endogenous steroid production. Four cases of exophthalmos associated with prolonged high doses of exogenous steroids are presented. Prior to steroid therapy, these patients exhibited no signs of exophthalmos. They were euthyroid with normal thyroid function studies while on steroid therapy. One case demonstrated a reduction of her exophthalmos after her steroid dosage was markedly decreased. Other known complications of steroid therapy including hyperglycemia, posterior subcapsular cataracts, and elevated intraocular tensions were found. The finding of exophthalmos presents a previously unreported complication of steroid therapy.