Patients undergoing unplanned extracapsular cataract extractions were studied for the appearance of lens induced uveitis and the development of antilens antibodies. Of the 64 patients in this group, 28 developed signs and symptoms which fulfilled the criteria for lens-induced uveitis. Using the passive hemagglutination technique two patients had demonstrable serum antilens antibodies at the time of surgery. During the period of observation postoperatively, 14 patients demonstrated the appearance of antibodies de novo. Thirteen of these patients with antilens antibodies suffered from uveitis. Most of the patients having lens-induced uveitis and antilens antibodies had a significant amount of lens material in the anterior chamber.
A second group of patients examined after the onset of a uveitis suggestive of being lensinduced were similarly studied for the presence of antilens antibodies. Of 13 in this group, seven demonstrated significant titers by hemagglutination. Using the technique of double diffusion in agar it could be demonstrated that these antibodies cross reacted with human-uveal antigen.
Lens-induced uveitis is considered to be an auto-immune disease and the significance of these immunologic findings is discussed.
Emil Wirostko, Harold F. Spalter. Lens-Induced Uveitis. Arch Ophthalmol. 1967;78(1):1–7. doi:10.1001/archopht.1967.00980030003001