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July 1967

Localization of Herpes Simplex Antigen and Virus: In the Corneal Stroma of Experimental Herpetic Keratitis

Arch Ophthalmol. 1967;78(1):68-73. doi:10.1001/archopht.1967.00980030070013

Herpes simplex virus antigen was localized in the corneal stroma of rabbits with experimental keratitis by the fluorescent antibody (FA) technique of Coons. Stromal localization appeared to be in keratocytes. The specificity of this localization by the FA stain was proved by electron micrographs.