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July 1967

Localization of Herpes Simplex Antigen and Virus: In the Corneal Stroma of Experimental Herpetic Keratitis

Author Affiliations

San Francisco
From the Francis I. Proctor Foundation for Research in Ophthalmology, and the Department of Ophthalmology, University of California, San Francisco Medical Center. Dr. Tanaka, formerly of the Department of Ophthalmology, Yokohama University School of Medicine, Yokohama, Japan, is a Fight-for-Sight research fellow of the National Council to Combat Blindness, Inc.

Arch Ophthalmol. 1967;78(1):68-73. doi:10.1001/archopht.1967.00980030070013

Herpes simplex virus antigen was localized in the corneal stroma of rabbits with experimental keratitis by the fluorescent antibody (FA) technique of Coons. Stromal localization appeared to be in keratocytes. The specificity of this localization by the FA stain was proved by electron micrographs.

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