A tonographic study of one pilocarpine hydrochloride-physostigmine (eserine) salicylate combination did not disclose any evidence of additive effects. A study of several combinations of miotics with levo-epinephrine hydrochloride revealed truly additive effects, probably due to functional interaction of the drugs involved. The study suggests that epinephrine exerts its resistance-lowering effect by action on essentially the same section of the outflow channels as that influenced by the miotics.
Kronfeld PC. The Efficacy of Combinations of Ocular Hypotensive Drugs: A Tonographic Approach. Arch Ophthalmol. 1967;78(2):140–146. doi:10.1001/archopht.1967.00980030142006
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