The nonnecrotizing, toxic ocular inflammation produced following conjunctival instillation of acacia or pyracanthus extract was clinically characterized by severe hyperemia, chemosis, subepithelial hemorrhage, purulent exudation of the conjunctiva and limbus, and iris hyperemia. The cornea remained remarkably free of disease throughout this reaction. Histopathology was characterized by massive proliferation of polymorphonuclear leukocytes in conjunctival and limbal tissues. The severity of this reaction was dependent on age and correlated with the level of circulating γ-globulin.