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September 1967

Mechanisms of the Host Response in the Eye: V. Anterior Ocular Disease Produced by Nonnecrotizing Toxic Agents

Author Affiliations

San Francisco
From the Eye Research Laboratories, Department of Ophthalmology, and the Clinical Laboratories, University of California School of Medicine at San Francisco General Hospital, San Francisco.

Arch Ophthalmol. 1967;78(3):384-396. doi:10.1001/archopht.1967.00980030386023

The nonnecrotizing, toxic ocular inflammation produced following conjunctival instillation of acacia or pyracanthus extract was clinically characterized by severe hyperemia, chemosis, subepithelial hemorrhage, purulent exudation of the conjunctiva and limbus, and iris hyperemia. The cornea remained remarkably free of disease throughout this reaction. Histopathology was characterized by massive proliferation of polymorphonuclear leukocytes in conjunctival and limbal tissues. The severity of this reaction was dependent on age and correlated with the level of circulating γ-globulin.

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