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October 1967

Precipitous Mental Deterioration Following Cycloplegia With 0.2% Cyclopentolate HC1

Author Affiliations

Rochester, NY
From the Department of Psychiatry, Strong Memorial Hospital, Rochester, NY. Dr. Carpenter is presently with the Adult Psychiatry Branch, National Institute of Mental Health, Bethesda, Md.

Arch Ophthalmol. 1967;78(4):445-447. doi:10.1001/archopht.1967.00980030447006

Following instillation of four drops of a solution of 0.2% cyclopentolate hydrochloride, 1% phenylephrine hydrochloride, with 3% polyvinylpyrrolidone in buffered isotonic base with 0.5% chlorbutanol as a preservative (cyclomydril), an 82-year-old man showed a decompensation of a previously compensated chronic dementia. It is postulated that he became delirious as reported in other cases following administration of 1% or 2% cyclopentolate. Further, his failure to recover the status quo ante was felt to represent a more general phenomenon; namely, the inability to regain coping mechanisms established at a time when the mental apparatus was capable of a higher order of function.

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