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October 1967

Spontaneous Nonpigmented Iris Cysts

Author Affiliations

Washington, DC
From the Registry of Ophthalmic Pathology, Armed Forces Institute of Pathology, Washington, DC. Dr. Naumann was a Fellow in Ophthalmic Pathology at the Armed Forces Institute of Pathology on leave from the University Eye Hospital, Hamburg, Germany, which is his present address. Dr. Green is a Special Fellow in Ophthalmic Pathology, National Institute of Neurological Diseases and Blindness, National Institutes of Health, at the Armed Forces Institute of Pathology Washington, DC.

Arch Ophthalmol. 1967;78(4):496-500. doi:10.1001/archopht.1967.00980030498016

EPITHELIAL cysts arising spontaneously in the iris are classified in two groups—intra-epithelial and stromal.1 The intra-epithelial cysts are made up of pigmented epithelium, and they are regarded as remnants of von Szily's marginal sinus of the iris that have not been obliterated.2-3

The stromal cysts are situated within the iris stroma and are lined by nonpigmented epithelium. The latter may be multilayered and may contain goblet cells. The origin of these cysts is still controversial.2-5 Some observers hold the opinion that they arise from the surface ectoderm displaced, probably, at the time of formation of the lens vesicle.6-8 Others9-12 believe that they develop from aberrant cells from the most anterior portion of the optic vesicle whiel it is still unpigmented. The histopathologic features of such cysts excised by iridectomy have been illustrated repeatedly,1,7-9, 13-18 but we have found only one report describing such