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January 1968

Acquired Cone Dysfunction and

Author Affiliations

From Howe Laboratory of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary (Dr. Zweifach), and Retina Service, Massachusetts Eye and Ear Infirmary (Dr. Wolf), Boston. Dr. Zweifach's present address is 525 E 68th St, New York 10021.

Arch Ophthalmol. 1968;79(1):18-21. doi:10.1001/archopht.1968.03850040020007

The similarity in symptomatology of acquired cone dysfunction syndrome and certain optic nerve diseases led to a comparison of these disorders. Without prolonged follow-up, clinical differentiation was usually quite difficult. Aberrations in retinal function tests that have been considered typical of cone dysfunction were also found in these optic neuropathies. It was concluded that abnormalities in these tests were not specific for the cones and indicated a disturbance anywhere within the photopic visual system. However, patients with cone dysfunction regularly demonstrated improvement in acuity with reduction in illumination in contrast to normals and patients with optic nerve or macular disease. This response was found to be a clinically significant factor.

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