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January 1968

Histopathology of Juvenile Retinoschisis

Author Affiliations

Philadelphia; Washington, DC
From the Department of Ophthalmology and the Laboratory of Surgical Pathology, Hospital of the University of Pennsylvania, Philadelphia, and the Registry of Ophthalmic Pathology, Armed Forces Institute of Pathology, Washington, DC (Dr. Zimmerman). Doctor Rahn is now at the Division of Ophthalmology, Meadowbrook Hospital, Hempstead, NY.

Arch Ophthalmol. 1968;79(1):49-53. doi:10.1001/archopht.1968.03850040051014

Our clinicopathologic data in a familial case of juvenile retinoschisis are presented. The schisis is seen histologically as a splitting of the sensory retina, predominantly within the nerve fiber layer. This site of splitting differs from that observed in the typical case of senile retinoschisis, in which the splitting occurs in the middle layers of the sensory retina. The histologic appearance observed in juvenile retinoschisis, however, is quite similar to that found in nonfamilial cases of retinoschisis in infants. A brother of the patient also had bilateral juvenile retinoschisis. The patient's other six siblings (all male) and both parents are free of the disorder. To our knowledge, this is the first histopathologic report of familial juvenile retinoschisis in a well-documented case.

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