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January 1968

Quantitative Steroid Effect on Graft Reaction

Author Affiliations

Gainesville, Fla
From the Department of Ophthalmology, College of Medicine, University of Florida, Gainesville.

Arch Ophthalmol. 1968;79(1):64-68. doi:10.1001/archopht.1968.03850040066018

Weak concentrations of topical corticosteroids were completely effective in the suppression of graft reactions elicited by full-thickness buttons of pig cornea placed interlamellarly in rabbit corneas. Dexamethasone 0.001% three times a day prevented any graft reactions. The mechanism of this suppression seems to depend mainly on the local anti-inflammatory action of the topical corticosteroids. The experimental model as described appears to be a reliable method of quantitative anti-inflammatory assay of topical solutions.