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February 1968

Systemic Absorption of Topical Steroids

Author Affiliations

From The Wilmer Ophthalmological Institute and Department of Pediatrics, The John Hopkins University School of Medicine and Hospital, Baltimore.

Arch Ophthalmol. 1968;79(2):174-176. doi:10.1001/archopht.1968.03850040176013

To measure the extent of systemic absorption of topical steroids, urinary excretion of 17-hydroxycorticosteroids and endogenous cortisol production rates were determined in four patients during a control period and then while receiving topical steroids. During the experimental period each patient received dexamethasone 0.01%, one drop to each eye every two hours. All four patients showed a marked reduction in corticosteroid production while receiving the topical medication.