The recent demonstration of discrete areas of fluorescein leakage in central serous retinopathy has permitted a new therapeutic approach in carefully selected cases. The fluorescein leakage site in four patients whose symptoms had persisted from 3½ to 34 months were treated with minimal intensity laser photocoagulation. Resolution of the serous detachment of the macula was obtained in each case with consequent improvement in visual acuity. Serial fundus photographs and fluorescein studies are presented. The techniques employed and the hazards of this form of therapy are discussed. It is stressed that until additional confirmation of this work is obtained this therapeutic approach is not to be recommended for general use.