THERE are two retinal structures which are able to proliferate upon irritation. These are the retinal pigment epithelium and the retinal glial cells, especially the astrocytes. Both these elements are involved in the formation of chorioretinal scars. They heal defects and may close holes. But they frequently overshoot this reparative process forming a circumscribed or diffuse glial scar or a pseudoepitheliomatous hyperplasia of the retinal pigment epithelium. The vagaries of these two retinal structures have recently been discusses.1,2
It is, however, extremely rare to find the glial elements or the retinal pigment epithelium invading the choroid. Before this occurs a definite break has to occur in Bruch's membrane allowing retinal elements to infiltrate the choroid. It is our intention to show that such an occurrence is characteristic for a syphilitic chorioretinitis.
The first two descriptions of such choroidal invasions come indeed from eyes with syphilitic disseminate chorioretinitis.3,4 This
Blodi FC, Hervouet F. Syphilitic Chorioretinitis: A Histologic Study. Arch Ophthalmol. 1968;79(3):294–296. doi:https://doi.org/10.1001/archopht.1968.03850040296013
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: