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April 1968

Experimental Toxoplasmic Retinochoroiditis

Author Affiliations

San Francisco
From Francis I. Proctor Foundation for Research in Ophthalmology and Department of Ophthalmology, University of California San Francisco Medical Center. Dr. Nozik is a recipient of Special National Institutes of Health research fellowship 1 F11 NB1649-01 VSN.

Arch Ophthalmol. 1968;79(4):485-489. doi:10.1001/archopht.1968.03850040487016

The technique of suprachoroidal space injection was utilized to produce experimental toxoplasmic retinochoroiditic lesions in rabbits. The lesion produced by the injection of the Beverley strain of Toxoplasma gondii closely resembled the naturally occurring disease in man, but it was less exudative and regressed spontaneously after only two to three weeks of activity. This experimental model may prove to be of use in studying pathogenetic mechanisms and therapy in this disease.

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