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May 1968

Opsoclonus, Body Tremulousness, and Benign Encephalitis

Author Affiliations

From Howe Laboratory of Ophthalmology, Harvard University Medical School, and Massachusetts Eye and Ear Infirmary, Boston.

Arch Ophthalmol. 1968;79(5):545-551. doi:10.1001/archopht.1968.03850040547009

Ten patients are described exemplifying a syndrome characterized by intermittent oscillations of the eyes, severe body tremulousness, and evidence of a benign encephalitis. The ocular movements accord with the definition of opsoclonus. The body tremulousness is related to posture but without other cerebellar signs. The encephalitis is mild and manifest chiefly by pleocytosis in the cerebrospinal fluid. The disease usually follows in the wake of an upper respiratory infection and resolves characteristically without sequela within a few weeks' time. Attempts to recover a virus have been uniformly unsuccessful.

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