Fluorescein photography has been performed on two patients with typical intact vitelliform macular lesions, and on an affected sibling of one of these patients who presumably has a later stage of the disorder. The patients with typical intact lesions showed normal fluorescein patterns, and the patient with an ophthalmoscopic appearance of retinal pigment disturbance demonstrated a fluorescein pattern indicating a defect in the retinal pigment epithelium. The significance of this observation in relation to the presumed site of the initial vitelliform abnormality is discussed.