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September 1968

Intranuclear Urate Crystals in Corneal Epithelium

Author Affiliations

From the Cornea Service, Massachusetts Eye and Ear Infirmary, the Department of Cornea Research, Institute of Biological and Medical Sciences, Retina Foundation, and Howe Laboratory of Ophthalmology, Harvard Medical School, Boston. Dr. Slansky is the recipient of Special Fellowship 1-F11-NB-1789-01 from the National Institute of Neurological Diseases and Blindness, Public Health Service.

Arch Ophthalmol. 1968;80(3):338-344. doi:10.1001/archopht.1968.00980050340008

Intranuclear deposition of urate crystals was demonstrated in the corneal epithelium of a patient with gout. The crystals were either hexagonal, octagonal, or cylindrical in shape and were composed of a regular lattice structure. Factors such as pH, temperature, avascularity, and increased purine metabolism, which affect the precipitation of urate crystals, are discussed in relation to the corneal epithelium.