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October 1968

Short-Term Tests of Anticholinergic Medication in Open-Angle Glaucoma

Author Affiliations

From the Massachusetts Eye and Ear Infirmary (Glaucoma Consultation Service) and Howe Laboratory of Ophthalmology, Harvard Medical School, Boston.

Arch Ophthalmol. 1968;80(4):443-448. doi:10.1001/archopht.1968.00980050445007

Published evidence appears to be inadequate to establish whether there is significant hazard in administering systemic medications with anticholinergic properties to patients who have primary open-angle glaucoma. Tests have been made in 28 patients with this type of glaucoma, showing that, although by applying an anticholinergic agent directly to the eyes it was possible to cause a prompt rise of at least 5 mm Hg in ocular pressure in half of the patients, when atropine sulfate was administered orally (two doses of 0.6 mg), it did not appreciably influence the pressure in a test period of seven to eight hours. The influence of cumulative repeated doses over a longer time remains to be determined.

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