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December 1968

Combination Therapy in Retinoblastoma: A 15-Year Summary of Methods and Results

Author Affiliations

New York
From the departments of medicine, ophthalmology, surgery, and radiotherapy, Columbia University College of Physicians and Surgeons, and the Columbia-Presbyterian Medical Center and the Institute of Ophthalmology, New York.

Arch Ophthalmol. 1968;80(6):744-746. doi:10.1001/archopht.1968.00980050746012

Results of combination chemotherapy and radiation therapy of bilateral retinoblastoma in a group of 307 patients treated from 1953 to 1966 are reported. An overall "cure rate" of 55% with useful vision is being achieved as compared to 23% prior to 1953 with radiation only. In the patients with less advanced disease (groups 1, 2, and 3) results of "cure" ranged from 60% to 87%. The development of the present therapeutic regimen and the future trends in the program are outlined.