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February 1969

Congenital Cataract in the Rat

Author Affiliations

Bethesda, Md
From the Ophthalmology Branch, National Institute of Neurological Diseases and Blindness (Dr. Smith), Laboratory of Biology, National Cancer Institute, National Institutes of Health (Dr. Hoffman), and the National Center for Radiological Health (Mr. Cisar), Public Health Service, Department of Health, Education, and Welfare, Bethesda, Md. Dr. Smith's current address is Department of Ophthalmology; Albany Medical College, Albany, NY.

Arch Ophthalmol. 1969;81(2):259-263. doi:10.1001/archopht.1969.00990010261020

A strain of Sprague-Dawley rats in which congenital cataracts are associated with skull malformations has been studied. The lens changes are nonprogressive and are found in newborn animals. Inheritance is by a fully-expressed simple autosomal recessive gene. Histopathologic study revealed a distinctive over production of the lens capsule and proliferation of lens epithelium which is a unique finding in animals and resembles changes seen in some human syndromes associated with congenital cataract.

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