A strain of Sprague-Dawley rats in which congenital cataracts are associated with skull malformations has been studied. The lens changes are nonprogressive and are found in newborn animals. Inheritance is by a fully-expressed simple autosomal recessive gene. Histopathologic study revealed a distinctive over production of the lens capsule and proliferation of lens epithelium which is a unique finding in animals and resembles changes seen in some human syndromes associated with congenital cataract.
Smith RS, Hoffman H, Cisar C. Congenital Cataract in the Rat. Arch Ophthalmol. 1969;81(2):259–263. doi:10.1001/archopht.1969.00990010261020
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