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March 1969

Collagenolytic Activity of Alkali-Burned Corneas

Author Affiliations

New York
From the Cornea Research Laboratory, Department of Ophthalmology, New York Hospital-Cornell University Medical School, New York.

Arch Ophthalmol. 1969;81(3):370-373. doi:10.1001/archopht.1969.00990010372015

Collagenolytic activity of alkali-burned corneas of rabbits was investigated using a tissue-culture assay technique. The technique was standardized, and in every instance, tissues from the immediate vicinity of the ulcers or perforations showed substantial collagenase production, while generally, tissues more than 2 mm away from the lesions were free of enzyme activity.

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