Young adult rhesus monkeys were inoculated at one session with homologous or bovine retina emulsified in Freund's complete adjuvant. Additional monkeys were sensitized with homologous choroid plexus and guinea pig kidney. All animals injected with homologous retina developed signs of intraocular inflammation in contrast to entirely negative results obtained with the use of other antigens. The histopathologic changes consisted of uveitis of varying extent and severity and periphlebitic lesions of the retina which, in the majority of animals, did not appear to be related to the focal choroidal inflammation.