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April 1969

Suppression of the Corneal Homograft Reaction by Antilymphocyte Serum

Author Affiliations

San Francisco
From the Francis I. Proctor Foundation for Research in Ophthalmology, University of California San Francisco Medical Center, San Francisco.

Arch Ophthalmol. 1969;81(4):571-576. doi:10.1001/archopht.1969.00990010573020

In from nine to 14 days, rabbits previously sensitized to their donors' tissues started to reject the rabbit corneal buttons that had been placed in their vascularized corneas. Systemically administered antilymphocyte serum (ALS) significantly retarded or prevented the development of the graft reaction during a 40-day observation period. Animals receiving normal horse serum or ALS systemically developed signs of anaphylaxis and serum sickness after repeated injections.

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