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June 1969

Heredity in Microtropia

Author Affiliations

From the Wilmer Institute of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore.

Arch Ophthalmol. 1969;81(6):753-757. doi:10.1001/archopht.1969.00990010755001

The motor and sensory ocular status of parents and siblings of 20 patients with microtropia was studied and was compared with the findings in 16 control subjects and their families. The data thus obtained indicate an uncommonly high incidence sensory, motor, and refractive anomalies in families of microtropic propositi. These anomalies included heterotropias and various sensory defects such as diminished fusional amplitudes, eccentric fixation, anomalous retinal correspondence, and deficient stereopsis. Analysis of the pedigrees of affected families suggests that microtropia is not a primary congenital defect inherited in any simple mendelian manner, but rather is caused by multiple and independently inherited sensory and motor anomalies.