Topical or systemic administration of synthetic double-stranded polyinosinic acid:cytidilic acid RNA prevented the establishment of herpetic keratoconjunctivitis in rabbits. The degree of systemic protection was directly related to the serum level of interferon induced.
Park JH, Galin MA, Billau A, Baron S. Prophylaxis of Herpetic Keratoconjunctivitis With Interferon InducersPreliminary Observations. Arch Ophthalmol. 1969;81(6):840–842. doi:10.1001/archopht.1969.00990010842016
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