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August 1969

Chromosome Studies in Patients With Retinoblastoma

Author Affiliations

From the Retina Service, Massachusetts Eye and Ear Infirmary, the James Homer Wright Pathology Laboratories, and the Joseph P. Kennedy, Jr., Laboratories of the Department of Neurology, Massachusetts' General Hospital, Boston.

Arch Ophthalmol. 1969;82(2):177-181. doi:10.1001/archopht.1969.00990020179005

Since there have been recent isolated reports of retinoblastoma associated with chromosomal defects, karyotypes were performed on 21 retinoblastoma patients (17 sporadic, 4 hereditary) in an attempt to associate a specific chromosomal abnormality with this disease. Chromosomes from a family with hereditary retinoblastoma were also studied using the new technique of scanning electron microscopy. No abnormalities were detected.

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