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August 1969

II. Histopathologic Manifestations of Mycoplasmal Uveitis

Arch Ophthalmol. 1969;82(2):253-258. doi:10.1001/archopht.1969.00990020255020

Histopathological study of experimental mycoplasma-induced uveitis revealed that within 24 to 48 hours of inoculating the infectious agent into the rabbit's anterior chamber, plasma, round cells, and polymorphonuclear leukocytes appeared in the anterior uveal tract. By the tenth day after inoculation there was a massive plasma cell infiltrate at the limbus and in the hyperemic, edematous irides and ciliary bodies. A moderate number of lymphocytes were also present in the reaction. In a few eyes there was very early infiltration of the choroid. By 20 days after inoculation, a significant number of eyes had become involved in a plasma cell panuveitis with secondary exudative retinal detachments. Over the ensuing weeks the process gradually resolved to leave eyes with fibrosed, thickened uveal tracts containing focal collections of lymphocytes. The significance of the immunologic events is discussed.

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