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August 1969


Author Affiliations

New Hyde Park, NY

Arch Ophthalmol. 1969;82(2):295. doi:10.1001/archopht.1969.00990020297031

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To the Editor.  —The editorial by Berson in the Archives (81:453 [April] 1969) presents an approach to the study of genetic-type disease, eg, retinitis pigmentosa, which has much merit.However, in my experience, numerous retinitis pigmentosa patients who have the disease maintain secrecy, so that evaluating their offspring would be a most difficult project to undertake.Nevertheless, if this could be done, 11-cis vitamin A or 11-cis retinene (which is now available) should be given a trial.In reviewing the results of my study using 11-cis vitamin A in the treatment of retinitis pigmentosa, a brother and sister under the age of 10 were treated, one received 11-cis vitamin A and the other all-trans vitamin A. The one given 11-cis vitamin A improved, the other given all-trans vitamin A regressed.Of course, this is statistically insignificant, but perhaps encouragement enough for someone in the field to pursue Dr. Berson's

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