Ophthalmic disease was described in three patients with the Wiskott-Aldrich syndrome, an entity characterized by eczema, thrombocytopenia, and recurrent infections, and inherited in a sex-linked fashion. Blepharoconjunctivitis. associated with molluscum contagiosum, and herpes simplex keratitis, isolated or accompanied by disseminated mucocutaneous herpes simplex virus infection or both, were found. In 18 of the 80 cases of the Wiskott-Aldrich syndrome documented in the literature, ocular complications were present.
Podos SM, Einaugler RB, Albert DM, Blaese RM. Ophthalmic Manifestations of the Wiskott-Aldrich Syndrome. Arch Ophthalmol. 1969;82(3):322–329. doi:10.1001/archopht.1969.00990020324005