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December 1969

The Effects of Inflammation on Experimentally Induced Vitreous Hemorrhage

Arch Ophthalmol. 1969;82(6):822-826. doi:10.1001/archopht.1969.00990020814017

Simulated vitreous hemorrhages were created using labeled blood in order to study the effects of inflammation on the resorption of erythrocytes and on the residual vitreous opacification caused by blood elements. The inflammatory response of allergic uveitis and infection accelerates the removal of intravitreal blood. Unfortunately, attempts to utilize this information clinically to hasten clearing of the eye will not be possible because inflammation increases the ocular damage caused by iron and hemoglobin. Cortisone acetate, which decreases the inflammatory response to intraocular hemorrhage had no beneficial or harmful effect. Mercaptopurine, another anti-inflammatory agent, not only delayed the resorption of the blood, but increased the residual vitreous opacification.