Collagenase was not produced in detectable quantities by the normal rabbit cornea. However, the corneas with full thickness wounds did produce enzyme. The epithelium contributed the great majority of the enzyme, and the production appeared to be triggered by an interaction with the stromal wound.
Brown SI, Weller CA. Cell Origin of Collagenase in Normal and Wounded Corneas. Arch Ophthalmol. 1970;83(1):74–77. doi:10.1001/archopht.1970.00990030076014
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