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January 1970

Cell Origin of Collagenase in Normal and Wounded Corneas

Author Affiliations

New York
From the Department of Ophthalmology, Cornea Research Laboratory, New York Hospital-Cornell University Medical Center, New York.

Arch Ophthalmol. 1970;83(1):74-77. doi:10.1001/archopht.1970.00990030076014

Collagenase was not produced in detectable quantities by the normal rabbit cornea. However, the corneas with full thickness wounds did produce enzyme. The epithelium contributed the great majority of the enzyme, and the production appeared to be triggered by an interaction with the stromal wound.