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February 1970

Transplantation Antigens in Keratoplasty: I. Isolation of a Soluble Fraction With Transplantation Antigen Activity

Author Affiliations

Boston; Fort Knox, Ky
From the Department of Ophthalmology, Boston University School of Medicine, Boston (Dr. Leibowitz), and the Biophysics Division, US Army Medical Research Laboratory, Fort Knox, Ky (Dr. Luzzio).

Arch Ophthalmol. 1970;83(2):215-222. doi:10.1001/archopht.1970.00990030217016

A soluble protein fraction has been isolated from the cornea by simple aqueous extraction. This preparation possesses transplantation antigen activity as demonstrated by its ability to induce a specific sensitization resulting in the accelerated destruction of a corneal graft. The corneal antigen preparation is also capable of stimulating the production of humoral antibodies, but the relationship between the transplantation immunity and the antibody response remains to be elaborated.