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March 1970

Ultrastructural and Histochemical Observations of Optic Nerve Gliomas

Author Affiliations

San Francisco
From the University of California Eye Pathology Laboratory and the Francis I. Proctor Foundation for Research in Ophthalmology, University of California Medical Center, San Francisco. Dr. Anderson is now at Bascom Palmer Eye Institute, Miami, Fla.

Arch Ophthalmol. 1970;83(3):324-335. doi:10.1001/archopht.1970.00990030326010

Colloidal iron stains showed that many optic nerve gliomas contain mucoid material. This material is extracellular, as demonstrated especially by electron microscopy of two gliomas. In one glioma it was particularly abundant and it apparently contributed to a sudden increase of proptosis due to rapid enlargement of the tumor. There was no evidence of necrosis or degeneration in these tumors, by light or by electron microscopy, and the accumulation of mucosubstance is not considered to be a degenerative change. The tumor cells were mainly astrocytes. These had certain embryonic ultrastructural features, but did not exhibit malignant alteration.

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